The antibiotic challenge: fighting multidrug-resistant bacteria

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About the research

Superbugs are outsmarting our antibiotics, but can science catch up?

Antibiotic resistance is one of the biggest threats to global health. As more bacteria evolve to resist treatment, we face a growing risk of once-treatable infections becoming deadly again. With few new antibiotics in development, the medical world is in urgent need of a new approach.
At Vrije Universiteit Brussel (VUB), researcher Richa Sharma is exploring a game-changing approach: instead of trying to kill harmful bacteria, her research focuses on weakening their ability to cause disease.
By chemically modifying parts of the bacteria that are essential for infection, her method reduces their impact, without immediately triggering resistance. The goal is to design antibiotics that are harder for bacteria to adapt to, giving us a safer, longer-lasting way to fight infections.

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Technology
Richa Sharma
VUB

Richa Sharma is a postdoctoral researcher at Vrije Universiteit Brussel, working in the field of organic and medicinal chemistry. She holds a PhD from Malaviya National Institute of Technology, Jaipur, where she focused on developing complex molecules inspired by natural products for pharmaceutical use.Her current research explores new ways to treat dangerous drug-resistant bacteria, like Acinetobacter baumannii, by targeting how they cause disease rather than trying to kill them directly — a promising strategy to stay ahead of antibiotic resistance.

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