Transforming drug testing with 3D cell culture

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About the research

Most new drugs never make it to market — but what if the problem is how we test them? Currently, many new medicines are first tested using 2D cell cultures — flat sheets of cells grown in petri dishes. But the human body is made of 3D tissues and organs, not flat layers. This mismatch often leads to misleading results and failed clinical trials. That is why Anubhav Bussooa (VUB) is developing 3D cell models that replicate the structure and complexity of real human tissues more closely. These tiny spheres even form root-like networks (inspired by how plants absorb nutrients) to help oxygen and nutrients reach every layer. Anubhav's research could improve drug testing, reduce failure rates, and accelerate the development of more effective and reliable treatments.

Health
Technology
Anubhav Bussooa
VUB

Anubhav has been fascinated by the biological world from a very young age. He has always been particularly interested in better understanding how the human body works. He is currently a postdoctoral researcher at Vrije Universiteit Brussel working on a relatively new field of research called Organ-on-Chip, which aims to develop simplified mini-organs in chips for more accurate drug testing. Specifically in his research, Anubhav is trying to address one of the major challenges: getting the mini-organs to develop a blood vessel network.

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